What is the APOE Gene? How can it affect a person's long term health?

What is the Apo E gene?

Apo is short for apolipoprotein. It has the letter “E” because it’s one of a whole series of apolipoproteins—A, B, C, D, etc. The Apo E gene gets its name from the fact that it’s the blueprint in charge of synthesizing apolipoprotein E, an important component of cholesterol and fat metabolism.

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How do you pronounce Apo E?

Apo E is pronounced by saying each letter separately....... A - P - O - E.

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Does everyone have an Apo E genotype?

Yes - The question is: which one do you have?

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How many variations are there of the Apo E gene?

There are three Apo E gene variations  that occur naturally in humans: Apo E 2, Apo E 3, and Apo E 4. Genes come in matching pairs, so we each have two copies of every gene (one from each parent). There are six possible combinations of Apo E gene pairs or genotypes. If you received an Apo E 2 from one parent and an Apo E 3 from the other parent, the shorthand description of your genotype is E 2/3. The six possible combinations are E 2/2, E 2/3, E 3/3, E 4/2, E 4/3, and E 4/4.

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Why is it important to know my Apo E genotype?

Your Apo E genotype greatly affects how your body processes carbohydrates, fats, and proteins, which in turn, affects your weight AND your predisposition toward certain chronic diseases, especially heart disease and Alzheimer's disease. 

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Once I know my Apo E genotype, can anything be done to reduce my risk of getting these chronic illnesses?

Yes. By adopting a diet and lifestyle that is appropriate for your particular Apo E genotype, you create a "gene-supportive environment (GSE)" for your Apo E genotype. Maintaining this "gene-supportive environment" dramatically reduces your risk of developing chronic diseases such as heart disease and Alzheimer's disease.

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Can the Apo E Gene Diet help me lose weight?

Yes. Following the dietary and lifestyle guidelines specific to your particular Apo E genotype enables your body to more efficiently process carbohydrates, fats, and proteins. In essence, the Apo E Gene Diet creates a customized plan for your body to help you lose weight, while at the same time minimizing your risk of developing chronic diseases.

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Is the Apo E Gene Diet the same for everyone?

No. That’s what so unique about this diet. There are six Apo E genotypes, and each genotype processes food in a unique way. Accordingly, there are specific optimal diet and exercise guidelines for each of the six Apo E genotypes.

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How do I find out what my Apo E gene type is?

Learning your Apo E genotype can be accomplished by performing a cheek swab test in our office.

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Can I get my Apo E gene test at any lab?

No. The Apo E gene test is a specialized test – not all labs perform this test.

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Do I need to fast for the Apo E gene test?

No. Fasting is not required because we are only examining genetic material.